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Contraindicated (one)nirmatrelvir/ritonavir will increase the stage or impact of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism.rufinamide will decrease the extent or influence of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.tipranavir will increase the stage or influence of triazolam